Resources for Managing
Seizure Clusters

Seizure clusters can be difficult to manage, given their unpredictable nature. But along with VALTOCO® (diazepam nasal spray), you have resources that can help.

Tent

DOWNLOADABLE Resources

Feel free to save any or all of these documents to help you along your seizure cluster journey.

VALTOCO doctor discussion guide

Doctor Discussion Guide

This can help you when it’s time to talk to your healthcare provider about VALTOCO.

Get the Guide

VALTOCO tip sheet

Tip Sheet

Follow these simple steps to ensure you receive the VALTOCO you’ve been prescribed.

Get the Tip Sheet

VALTOCO instructions for use

Instructions for Use

Give this document to care partners, like friends, family, and coworkers, so that they know how to use VALTOCO to help treat your seizure clusters.

Get the Instructions

VALTOCO track your seizure clusters

Track Your Seizure Clusters

Documenting your seizure clusters can help you better understand when and where they occur. Download the app from Seizure Tracker™.

VALTOCO patient brochure

Patient Brochure

Get the guidance you need, including answers, tips, and resources, to help you carry VALTOCO with confidence.

Get the Brochure

Prescription Expiration Reminder

For your VALTOCO to work most effectively, make sure your on-hand rescue medication stays current. You can make sure you have fresh doses ready for you by identifying the expiration date of your VALTOCO.

VALTOCO bitmap

You can find the expiration date of your VALTOCO by looking at the VALTOCO box and blister pack.

VALTOCO bitmap

Set a Calendar Reminder

When Does Your Product Expire?

Please select an expiration month above.

Please select an expiration year above.

Please select an expiration month and year above.

Set A Reminder

It’s time to refill your VALTOCO prescription

For Google: Your calendar will pop up. Don’t forget to save it.

For iCal and Outlook: The file will download. Double-click it.

Savings and Support for VALTOCO

If eligible, you may pay as little as $20 with the VALTOCO copay card.

Find Out More

Online RESOURCES

There are communities and resources that champion the needs of those living with epilepsy and seizure clusters. Get familiar with them and, if it’s right for you, empower yourself by getting involved.

Epilepsy Foundation logo

EPILEPSY FOUNDATION

With a network of nearly 50 partners throughout the United States, the Epilepsy Foundation connects people to treatment, support, and resources. Visit epilepsy.com for more information.

Visit

National Institute of Neurological Disorders and Stroke (NINDS) logo

NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS)

NINDS conducts and funds research on brain and nervous system disorders.

Visit

The NIH does not endorse or promote any particular products or services

Child Neurology Foundation logo

CHILDHOOD NEUROLOGY FOUNDATION (CNF)

CNF is a collaborative center of education and support for children and their families living with neurologic conditions.

Visit

Dravet Syndrome Foundation logo

DRAVET SYNDROME FOUNDATION (DSF)

DSF was founded by a group of parents with the purpose of supporting and funding research for Dravet syndrome and related epilepsies. The organization is committed to increasing awareness and providing support to affected individuals and families.

Visit

LGS Foundation logo

LGS FOUNDATION

The LGS Foundation's mission is to improve the lives of those affected by Lennox-Gastaut syndrome (LGS)—a rare epilepsy syndrome—through research, family support programs, and education.

Visit

CURE logo

CITIZENS UNITED FOR RESEARCH IN EPILEPSY (CURE)

CURE is a leading organization that is fully committed to finding a cure for epilepsy by promoting and funding patient-focused research.

Visit

EAA logo

EPILEPSY ALLIANCE AMERICA (EAA)

EAA is a new national organization dedicated to providing support, care, and services for people with epilepsy and their communities.

Visit

Tuberous Sclerosis Alliance logo

TUBEROUS SCLEROSIS (TS) ALLIANCE

The TS Alliance is dedicated to finding a cure for tuberous sclerosis complex, while improving the lives of those affected by this genetic disorder.

Visit

more information on seizure treatment

Get savings and support for VALTOCO and, if eligible, you may pay as little as $20 with the VALTOCO copay card.

IMPORTANT SAFETY INFORMATION,
INCLUDING BOXED WARNING

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Important Safety Information you should know about VALTOCO® (diazepam nasal spray), CIV

What is the most important information I should know about VALTOCO?

  • VALTOCO is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death.
  • VALTOCO can make you sleepy or dizzy and can slow your thinking and your motor skills. Do not drive, operate heavy machinery, or do other dangerous activities until you know how VALTOCO affects you.
  • Like other antiepileptic drugs, VALTOCO may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
    • Thoughts about suicide or dying
    • Feeling agitated or restless
    • Acting aggressive, being angry, or violent
    • Attempts to commit suicide
    • Panic attacks
    • Acting on dangerous impulses
    • Trouble sleeping (insomnia)
    • An extreme increase in activity and talking (mania)
    • New or worse anxiety
    • New or worse irritability
    • Other unusual changes in behavior or mood
    • New or worse depression

How can I watch for early symptoms of suicidal thoughts or actions?

  • Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings.
  • Keep all follow-up visits with your healthcare provider as scheduled.
  • Call your healthcare provider between visits as needed, especially if you are worried about symptoms. Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.

Do not use VALTOCO if you:

  • Are allergic to diazepam.
  • Have an eye problem called acute narrow-angle glaucoma.

What should I tell my doctor before taking VALTOCO?

Before using VALTOCO, tell your healthcare provider about all of your medical conditions, including if you:

  • Have asthma, emphysema, bronchitis, chronic obstructive pulmonary disease, or other breathing problems.
  • Have a history of alcohol or drug abuse.
  • Have a history of depression, mood problems, or suicidal thoughts or behavior.
  • Have liver or kidney problems.
  • Are pregnant or plan to become pregnant. VALTOCO may harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. VALTOCO passes into your breast milk and may harm your baby. Talk to your healthcare provider about the best way to feed your baby if you use VALTOCO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use VALTOCO?

  • Read the Instructions for Use for detailed information about the right way to use VALTOCO.
  • Use VALTOCO exactly as prescribed by the healthcare provider.
  • Your healthcare provider will tell you:
    • What seizure clusters are
    • Exactly how much VALTOCO to give
    • When to give VALTOCO
    • How to give VALTOCO
    • What to do after you give VALTOCO if the seizures do not stop or there is a change in breathing, behavior, or condition that worries you
  • You should carry VALTOCO with you in case you need to control your seizure clusters.
  • Family members, care providers, and other people who may have to give VALTOCO should know where you keep your VALTOCO and how to give VALTOCO before a seizure cluster happens.
  • VALTOCO is given in the nose (nasal) only.
  • VALTOCO comes ready to use.
  • Each VALTOCO only sprays 1 time and cannot be reused. Do not test or prime the nasal spray before use.
  • Each dose of VALTOCO is provided in an individual pack. Use all of the medicine in 1 pack for a complete dose.

What should I do after I give VALTOCO?

  • Stay with the person after you give VALTOCO and watch them closely.
  • Keep or move the person onto their side.
  • Make a note of the time VALTOCO was given.
  • Call for emergency help if any of the following happen:
    • Seizure behavior is different than other seizures the person has had.
    • You are alarmed by how often the seizures happen, by how severe the seizure is, by how long the seizure lasts, or by the color or breathing of the person.
  • Throw away (discard) the used VALTOCO.

If needed, a second dose may be given at least 4 hours after the first dose, using a new pack of VALTOCO. Do not give more than 2 doses of VALTOCO to treat a seizure cluster.

A second dose should not be given if there is concern about the person's breathing, they need help with their breathing, or have extreme drowsiness.

Do not use VALTOCO for more than 1 seizure cluster episode every 5 days. Do not use VALTOCO for more than 5 seizure cluster episodes in 1 month.

What should I avoid while using VALTOCO?

  • Do not drink alcohol or take opioid medicines that make you sleepy or dizzy while taking VALTOCO until you talk to your healthcare provider. When taken with alcohol or medicines that can cause sleepiness or dizziness, VALTOCO may make your sleepiness or dizziness worse.

What are the most common side effects of VALTOCO?

The most common side effects of VALTOCO include:

  • Feeling sleepy or drowsy
  • Headache
  • Nose discomfort

These are not all of the possible side effects of VALTOCO. Call your healthcare provider for medical advice about side effects. You may report side effects to Neurelis, Inc. at 1-866-696-3873 or to FDA at 1-800-FDA-1088.

Please see full Prescribing Information and Medication Guide for additional important safety information.

What is VALTOCO® (diazepam nasal spray)?

  • VALTOCO is a prescription medicine used for the short-term treatment of seizure clusters (also known as “acute repetitive seizures”) in patients 6 years of age and older.
  • VALTOCO is a federal controlled substance (CIV) because it can be abused or lead to dependence. Keep VALTOCO in a safe place to prevent misuse and abuse. Selling or giving away VALTOCO may harm others and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription drugs, or street drugs.
  • It is not known if VALTOCO is safe and effective in children under 6 years of age.

IMPORTANT SAFETY INFORMATION

Important Safety Information you should know about VALTOCO® (diazepam nasal spray), CIV

What is the most important information I should know about VALTOCO?

  • VALTOCO is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death.
  • VALTOCO can make you sleepy or dizzy and can slow your thinking and your motor skills. Do not drive, operate heavy machinery, or do other dangerous activities until you know how VALTOCO affects you.
  • Like other antiepileptic drugs, VALTOCO may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
    • Thoughts about suicide or dying
    • Feeling agitated or restless
    • Acting aggressive, being angry, or violent
    • Attempts to commit suicide
    • Panic attacks
    • Acting on dangerous impulses
    • Trouble sleeping (insomnia)
    • An extreme increase in activity and talking (mania)
    • New or worse anxiety
    • New or worse irritability
    • Other unusual changes in behavior or mood
    • New or worse depression

How can I watch for early symptoms of suicidal thoughts or actions?

  • Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings.
  • Keep all follow-up visits with your healthcare provider as scheduled.
  • Call your healthcare provider between visits as needed, especially if you are worried about symptoms. Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.

Do not use VALTOCO if you:

  • Are allergic to diazepam.
  • Have an eye problem called acute narrow-angle glaucoma.

What should I tell my doctor before taking VALTOCO?

Before using VALTOCO, tell your healthcare provider about all of your medical conditions, including if you:

  • Have asthma, emphysema, bronchitis, chronic obstructive pulmonary disease, or other breathing problems.
  • Have a history of alcohol or drug abuse.
  • Have a history of depression, mood problems, or suicidal thoughts or behavior.
  • Have liver or kidney problems.
  • Are pregnant or plan to become pregnant. VALTOCO may harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. VALTOCO passes into your breast milk and may harm your baby. Talk to your healthcare provider about the best way to feed your baby if you use VALTOCO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use VALTOCO?

  • Read the Instructions for Use for detailed information about the right way to use VALTOCO.
  • Use VALTOCO exactly as prescribed by the healthcare provider.
  • Your healthcare provider will tell you:
    • What seizure clusters are
    • Exactly how much VALTOCO to give
    • When to give VALTOCO
    • How to give VALTOCO
    • What to do after you give VALTOCO if the seizures do not stop or there is a change in breathing, behavior, or condition that worries you
  • You should carry VALTOCO with you in case you need to control your seizure clusters.
  • Family members, care providers, and other people who may have to give VALTOCO should know where you keep your VALTOCO and how to give VALTOCO before a seizure cluster happens.
  • VALTOCO is given in the nose (nasal) only.
  • VALTOCO comes ready to use.
  • Each VALTOCO only sprays 1 time and cannot be reused. Do not test or prime the nasal spray before use.
  • Each dose of VALTOCO is provided in an individual pack. Use all of the medicine in 1 pack for a complete dose.

What should I do after I give VALTOCO?

  • Stay with the person after you give VALTOCO and watch them closely.
  • Keep or move the person onto their side.
  • Make a note of the time VALTOCO was given.
  • Call for emergency help if any of the following happen:
    • Seizure behavior is different than other seizures the person has had.
    • You are alarmed by how often the seizures happen, by how severe the seizure is, by how long the seizure lasts, or by the color or breathing of the person.
  • Throw away (discard) the used VALTOCO.

If needed, a second dose may be given at least 4 hours after the first dose, using a new pack of VALTOCO. Do not give more than 2 doses of VALTOCO to treat a seizure cluster.

A second dose should not be given if there is concern about the person's breathing, they need help with their breathing, or have extreme drowsiness.

Do not use VALTOCO for more than 1 seizure cluster episode every 5 days. Do not use VALTOCO for more than 5 seizure cluster episodes in 1 month.

What should I avoid while using VALTOCO?

  • Do not drink alcohol or take opioid medicines that make you sleepy or dizzy while taking VALTOCO until you talk to your healthcare provider. When taken with alcohol or medicines that can cause sleepiness or dizziness, VALTOCO may make your sleepiness or dizziness worse.

What are the most common side effects of VALTOCO?

The most common side effects of VALTOCO include:

  • Feeling sleepy or drowsy
  • Headache
  • Nose discomfort

These are not all of the possible side effects of VALTOCO. Call your healthcare provider for medical advice about side effects. You may report side effects to Neurelis, Inc. at 1-866-696-3873 or to FDA at 1-800-FDA-1088.

Please see full Prescribing Information and Medication Guide for additional important safety information.